AICAR
50mg
❄️Lyophilized powder (not reconstituted)
Discount per Quantity
| Quantity | Discount | Price per Unit |
|---|---|---|
| 5 - 10 | 10% | €26.99 |
| 11 - 20 | 15% | €25.49 |
| 21+ | 20% | €23.99 |
Rigorous third-party testing
Every batch of our research chemicals and peptides undergoes independent third-party laboratory testing for purity and identity.
Total: €29.99
AICAR is supplied as a catalogued research material in 50 mg.
The abbreviation “AICAR” is chemically ambiguous because it is used for both acadesine and AICA ribotide/ZMP. The exact species must be confirmed from the batch identity report before assigning formula or registry data [1,2].
Chemical properties and registry information
| Property | Value |
|---|---|
| Name and synonyms | AICAR, AICA-riboside, 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside |
| Material category | AMPK Activator |
| Sequence | 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside |
| Molecular formula | C9H14N4O5 |
| Average molecular mass | 258.23 g/mol |
| CAS Registry Number | 2627-69-2 |
| PubChem CID | CID 65110 |
| Structural features | Small molecule nucleoside analog. |
| Appearance | White to off-white lyophilised powder |
| Solubility | Readily soluble in water (e.g., >25 mg/mL) and DMSO. |
| Physical form | Catalogue vial; exact salt/counter-ion and excipients are batch-specific and must be verified in the CoA and SDS. |
Registry values apply only to the specific molecular entity, sequence, termini and material form. Batch records take precedence over family-level literature identifiers.
A cell-permeable nucleoside that is phosphorylated intracellularly to ZMP (AICAR monophosphate), an AMP analog that potently activates AMP-activated protein kinase (AMPK).
Research background and published evidence
Published research
Acadesine can enter cells and be phosphorylated by adenosine kinase to ZMP; both names appear in research on nucleotide metabolism and AMPK-associated signaling [3,4].
Current scientific understanding
AICAR-related observations are not exclusively AMPK-mediated, and findings for acadesine cannot be assigned automatically to supplied ZMP or vice versa. The literature does not establish the identity or performance of this catalogue batch.
Acadesine and AICA ribotide are distinct analytes; naming similarity does not establish chemical equivalence.
Technical comparison
| Aspect | This catalogue material | Comparator |
|---|---|---|
| Identity | Catalogue material named AICAR; exact riboside or ribotide identity requires batch confirmation | Defined acadesine/AICA riboside or defined AICA ribotide/ZMP reference standard |
| Structural distinction | The abbreviation alone does not establish the presence of a 5′-phosphate | The reference standard explicitly defines riboside versus 5′-phosphorylated ribotide |
| Analytical implication | Confirm phosphate state, salt and intact mass before selecting identifiers | Each defined reference has a different formula, mass, CAS number and PubChem CID |
Quality and testing
Quality information is batch- and presentation-specific. Use only the report linked to the exact size and lot. A report listed for another size, lot or similarly named material must not be treated as evidence for this product.
Chromatographic area purity, identity, net peptide or analyte content, water or counter-ion content, sterility, endotoxin and elemental impurities are different measurements. One result does not establish the others. Only tests supported by a visible, matching report should be regarded as available.
Laboratory handling and storage
Store and handle only under the conditions stated on the product label, batch CoA and SDS. Keep the container secured, correctly identified and protected from contamination. Do not infer storage, solvent compatibility or stability from a related compound.
Laboratory preparation, analytical-method selection, risk assessment, personal protective equipment and waste disposal should follow the applicable SDS and the institution's approved procedures.
Regulatory and legal status
| Research-use notice | This material is supplied exclusively for laboratory research by qualified professionals and is not intended for human or veterinary use. Purchasers are responsible for compliance with applicable local requirements. |
Sources and references
- [1] PubChem. Acadesine, CID 17513.
- [2] PubChem. AICA ribotide/ZMP, CID 65110.
- [3] Review of AICAR pharmacology and cellular conversion to ZMP.
- [4] Review of AMPK-dependent and AMPK-independent effects of AICAR.
Frequently Asked Questions
Do the CAS number and PubChem CID apply to every batch form?
Only when the exact sequence or structure, termini, conjugation, salt or counter-ion and hydration state match. The batch CoA and SDS govern; a related-compound identifier must not be substituted.
What does an analytical purity result mean?
It is method- and report-specific. For example, an HPLC area percentage is not automatically the same as identity, net content, sterility, endotoxin status or absence of elemental impurities.
How should the material be stored and handled?
Follow the exact label, batch CoA and SDS together with the institution's risk assessment. Use only storage and stability information linked to the exact material form and batch.